New Perspectives in Pharmaco-Electroencephalography
FGK_2005_Prog_Neuro-Psychopharm_BiolPsych_29-New_perspectives_in_pharmaco-EEG.pdf
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Abstract: Recent research emphasizes that majority of brain disorders and psychiatric problems are accompanied by disruption in the temporal structure of brain activity. From this perspective, disruption is viewed as a disorder of the metastable balance between large-scale integration and independent processing in the brain, in favor of either independent or hyper-ordered processing. This paper proposes that the future of psychopharmacology lies in its ability to design the psychotropic drugs which can restore the normal temporal structure and metastable structure of brain activity. Quantitative electroencephalography (QEEG) is one of the key complex technologies utilized in psychopharmacology for this purpose. However, conventional approaches for EEG analysis used in clinical practice are not suitable for studying temporal structure of brain activity. To overcome this limitation, and in order to reveal dynamic and temporal characteristics of brain activity, the advanced analysis of EEG micro-structure should be used. Key words: brain dynamics, EEG micro-structure, functional connectivity, lorazepam, mental disease, metastability, psychiatry, psychopharmacology, psychotropic drugs, temporal activity.
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2005, V. 29. No 2. P. 193-199.
- The interplay of lorazepam-induced brain oscillations : Microstructural electromagnetic study
- Enhancement of GABA-related signalling is associated with increase of functional connectivity in human cortex
- Local and remote functional connectivity of neocortex under the inhibition influence
- Making complexity simpler: Multivariability and metastability in the brain
- Functional connectivity in the brain - is it an elusive concept?
- Probability interrelations between pre-/post-stimulus intervals and ERD/ERS during a memory task
- The regularities of the discrete nature of multi-variability of EEG spectral patterns
- Cortical operational synchrony during audio-visual speech integration
- Multivariability and metastability of electromagnetic resonant states in the brain as a basis for cognition
- Operational architectonics of perception and cognition: A principle of self-organized metastable brain states
- Structural (operational) synchrony of EEG alpha activity during an auditory memory task
- Systematic rules underlying spectral pattern variability: Experimental results and a review of the evidences
- Operational architectonics of the human brain biopotential field: Towards solving the mind-brain problem
- Micro- and macrostructure of sleep EEG
- Multichannel MP + EEG IS
- Low Resoultion Electromagnetic Tomography software
- Movies: gamma activity flow in finger movement and its imagination
- Computationally efficient approaches to calculating significant ERD/ERS changes in the time-frequency plane
- Finding significant correlates of conscious activity in rhythmic EEG
Apr 28, 2006 12:00 PM
