The interplay of lorazepam-induced brain oscillations : Microstructural electromagnetic study

Abstract Objective: The effects on cortical rhythms of a single-dose (30 g/kg) administration of the GABAA agonist lorazepam were examined in a randomized, double-blind, cross-over, placebo-controlled study with 8 healthy volunteers using simultaneous electroencephalography (EEG) and magnetoencephalography (MEG). Methods: The oscillations were assessed by means of adaptive classification of short-term spectral patterns. Results: Lorazepam a) decreased the percentage of EEG/MEG segments with fast-theta, delta-alpha, fast-theta–alpha and alpha activity and increased percentage of EEG/MEG segments with delta, delta–slow-theta, delta-beta, slow-theta and polyrhythmic activity; b) decreased diversity of EEG/MEG signals (in terms of spectral patterns) and increased the general instability of the signal; c) increased stabilization periods of the spectral patterns (reduced brain information processing); d) maintained larger maximum periods of temporal stabilization for delta, slow-theta, delta–slow-theta, delta-beta and polyrhythmic activity (in terms of spectral patterns); e) did not increase power in the independent beta rhythm. Conclusion: Lorazepam caused significant reorganization of the EEG/MEG microstructure. These results suggest also that adaptive classification analysis of single short-term spectral patterns may provide additional information to conventional spectral analyses. Keywords: Adaptive classification, Electroencephalography (EEG), Lorazepam, Magnetoencephalography (MEG), Microstructure, Short-term spectral patterns.

Clinical Neurophysiology. 2004, V. 115. No 3. P. 674-690.

http://www.bm-science.com